欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-CIA1 free base
CIA1 free base

Chemical Structure : CIA1 free base

CAS No.: 452087-38-6

加入收藏

CIA1 free base (COUP-TFII inhibitor CIA1)

货号: PC-25580Not For Human Use, Lab Use Only.

CIA1 free base (COUP-TFII inhibitor A1) is a potent and specific inhibitor of COUP-TFII activity, inhibits COUP-TFII–driven NGFIA reporter expression with IC50 of 3.2 uM, disturbs COUP-TFII binding to FOXA1 to regulate target gene expression.

规格 价格 库存 数量
10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2280 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CIA1 free base (COUP-TFII inhibitor A1) is a potent and specific inhibitor of COUP-TFII activity, inhibits COUP-TFII–driven NGFIA reporter expression with IC50 of 3.2 uM, disturbs COUP-TFII binding to FOXA1 to regulate target gene expression.
CIA1 repressed NGFIA reporter expression in a COUP-TFII–dependent manner, as COUP-TFII knockdown abrogated CIA1-induced inhibition.
CIA1 directly interacts with COUP-TFII protein, CIA1 treatment resulted in a thermal stabilization of COUP-TFII.
CIA1 inhibited growth of multiple prostate cancer cell lines including androgen-sensitive LNCaP cells, AR-negative PC3 cells, as well as CRPC C4-2, abl, and AR variant 22Rv1 cells with IC50 of 1.2 to 7.6 uM, also notably inhibited the colony formation ability of prostate cancer cells in a dose-dependent manner.
COUP-TFII inhibitor CIA1 can phenocopy COUP-TFII silencing, with no apparent effect COUP-TFII protein levels, disturbed COUP-TFII target genes in tumor samples, including induced FOXM1, CDK1, and repressed p21.
COUP-TFII inhibitor CIA1 (2.6 mg/kg, i.p.) inhibited prostate cancer tumor growth in PC3 xenograft in the mice that bear PC3 xenograft, with limited toxicity.

物理化学性质&存储条件

分子量 329.42
分子式 C17H19N3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3,4-dimethoxyphenethyl)-6-methylthieno[2,3-d]pyrimidin-4-amine

参考文献

1. Leiming Wang, et al. Sci Adv. 2020 Apr 29;6(18):eaaz8031.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: