CI-994 (Tacedinaline) | class I HDAC inhibitor | Probechem Biochemicals

Chemical Structure : CI-994

CAS No.: 112522-64-2

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CI-994 (Acetyldinaline, Tacedinaline, PD-123654, Goe-5549)

货号: PC-45907Not For Human Use, Lab Use Only.

CI-994 (Tacedinaline) is a potent, selective class I HDAC inhibitor with IC50 of 0.9/0.9/1.2 uM for HDAC1/2/3, respectively.

规格	价格	库存
25 mg	￥580	In stock
50 mg	￥880	In stock
100 mg	￥1380	In stock
250 mg		Get quote

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生物&药学活性

CI-994 (Tacedinaline) is a potent, selective class I HDAC inhibitor with IC50 of 0.9/0.9/1.2 uM for HDAC1/2/3, respectively.
CI-994 show no significant inhibitory activity against HDAC8 (IC50>20 uM).
CI-994 reduces S phase level and increases apoptosis in A-549 and LX-1 cells.
CI-994 demonstrates antitumor activity against several tumor models, including the chemo-resistant mouse pancreatic ductal carcinoma as well as the human prostate tumor model LNCaP.

物理化学性质&存储条件

分子量	269.2985
分子式	C15H15N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 58 mg/mL
Chemical Name/SMILES	Benzamide, 4-(acetylamino)-N-(2-aminophenyl)-

参考文献

1. Moradei OM, et al. J Med Chem. 2007 Nov 15;50(23):5543-6.

2. el-Beltagi HM, et al. Cancer Res. 1993 Jul 1;53(13):3008-14.

3. Loprevite M, et al. Oncol Res. 2005;15(1):39-48.

CI-994 (Acetyldinaline, Tacedinaline, PD-123654, Goe-5549)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

CI-994 (Acetyldinaline, Tacedinaline, PD-123654, Goe-5549)

生物&药学活性

物理化学性质&存储条件

参考文献

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