CHI3L1 inhibitor 8

Chemical Structure : CHI3L1 inhibitor 8

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货号: PC-25746Not For Human Use, Lab Use Only.

CHI3L1 inhibitor 8 is a potent, CNS permeable small molecule inhibitor of chitinase-3-like protein 1 (CHI3L1) with dissociation constants (Kd) of 6.8 uM and SPR Kd of 5.69 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

CHI3L1 inhibitor 8 is a potent, CNS permeable small molecule inhibitor of chitinase-3-like protein 1 (CHI3L1) with dissociation constants (Kd) of 6.8 uM and SPR Kd of 5.69 uM.
CHI3L1 inhibitor 8 (10-50 uM) induces dose-dependent and significant reduction in spheroid viability in multicellular 3D GBM spheroid model.
CHI3L1 inhibitor 8 shows dose-dependent inhibition of pSTAT3, mirroring the effects of Hygromycin B (HB), a known CHI3L1-STAT3 disruptor.
CHI3L1 inhibitor 8 (10 uM) produces a robust antiangiogenic effect in CHI3L1-stimulated HMEC-1 tube-formation assay.

物理化学性质&存储条件

分子量	327.46
分子式	C17H17N3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((5-(methylthio)-1,3,4-thiadiazol-2-yl)methyl)-1,1-diphenylmethanamine

参考文献

1. Kaur B, et al. ACS Med Chem Lett. 2025 Nov 1;16(11):2346-2353.