CH7450924 | KEAP1-NRF2 inhibitor, NRF2 activator | Probechem Biochemicals

Chemical Structure : CH7450924

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CH7450924 (CH 7450924)

货号: PC-25720Not For Human Use, Lab Use Only.

CH7450924 is a highly potent and selective NRF2 activator, inhibits KEAP1-NRF2 interaction inhibitor, binds non-covalently to the NRF2 binding site of KEAP1.

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生物&药学活性

CH7450924 is a highly potent and selective NRF2 activator, inhibits KEAP1-NRF2 interaction inhibitor, binds non-covalently to the NRF2 binding site of KEAP1.
CH7450924 increased the expression of NQO1 mRNA, a target gene of NRF2, in human kidney cell line 293 with EC50 of 2.5 nM.
CH7450924 significantly reduced IL-6 and IL-1β mRNA in both organs, as well as TNFα mRNA in the kidney, in MODS model induced by intraperitoneal LPS injection.
CH7450924 significantly reduced inflammation, prevented structural damage, and improved respiratory function in lung injury model induced by intratracheal LPS injection.

物理化学性质&存储条件

分子量	649.16
分子式	C35H38ClFN4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[3-[2-chloro-4-[(2R,5R)-2,4,5-trimethylpiperazin-1-yl]benzoyl]-2,4-dihydro-1,3-benzoxazin-8-yl]-5-fluoro-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)benzoic acid

参考文献

1. Hoshino M, et al. Sci Rep. 2025 Oct 17;15(1):36413.

CH7450924 (CH 7450924)

生物&药学活性

物理化学性质&存储条件

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CH7450924 (CH 7450924)

生物&药学活性

物理化学性质&存储条件

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