CEP-28122 mesylate | ALK inhibitor | Probechem Biochemicals

Chemical Structure : CEP-28122 mesylate

CAS No.: 2070009-30-0

加入收藏

CEP-28122 mesylate (CEP28122 mesylate)

货号: PC-45405Not For Human Use, Lab Use Only.

CEP-28122 mesylate is a highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2280	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CEP-28122 mesylate is a highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.
CEP-28122 mesylate exhibits no-to-weak inhibition against a panel of 259 kinases and only 15 kinases showes >90% inhibition at 1 uM.
CEP-28122 mesylate shows growth inhibition/cytotoxicity of ALCL, NSCLC, and neuroblastoma cells, and displays dose-dependent inhibition of ALK tyrosine phosphorylation in tumor xenografts in mice (30 mg/kg).

物理化学性质&存储条件

分子量	635.1746
分子式	C29H39ClN6O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 6.4 mg/mL; DMSO < 9.2 mg/mL
Chemical Name/SMILES	Bicyclo[2.2.1]hept-5-ene-2-carboxamide, 3-[[5-chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-, (1S,2S,3R,4R)-, methanesulfonate (1:1)

参考文献

1. Cheng M, et al. Mol Cancer Ther. 2012 Mar;11(3):670-9.

2. Sullivan I, et al. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.

CEP-28122 mesylate (CEP28122 mesylate)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

CEP-28122 mesylate (CEP28122 mesylate)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.