CDRI-1709S

Chemical Structure : CDRI-1709S

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货号: PC-27859Not For Human Use, Lab Use Only.

CDRI-1709S is a highly potent, selective small molecule AdipoR1 (Adiponectin receptor 1) agonist with EC50 of 414.7 pM, activates adiponectin signalling via AdipoR1 but not AdipoR2.

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生物&药学活性

CDRI-1709S is a highly potent, selective small molecule AdipoR1 (Adiponectin receptor 1) agonist with EC50 of 414.7 pM, activates adiponectin signalling via AdipoR1 but not AdipoR2.
CDRI-1709S promoted C2C12 myoblast differentiation into mature myotubes, accompanied by increased expression of MyoD and myogenin.
CDRI-1709S also reverses Dexamethasone‐mediated impairments in oxidative and glycolytic capacity.
CDRI-1709S activated hallmark adiponectin‐associated signalling events, including phosphorylation of AMPK, AKT and p38‐MAPK, in AdipoR1‐overexpressing HEK293T and AdipoR‐rich C2C12 myotubes.
CDRI-1709S protected myotubes against Dexamethasone, LPS + TNFα and PBS (nutrient deficiency)‐induced atrophy.
CDRI-1709S prevented dexamethasone‐induced skeletal muscle atrophy in SD rats.

物理化学性质&存储条件

分子量	262.24
分子式	C15H11NaO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium 6a,11a-dihydro-6H-benzofuro[3,2-c]chromen-3-olate

参考文献

1. Md Rameez Moin, et al. J Cachexia Sarcopenia Muscle. 2026 Aug;17(4):e70328.

CDRI-1709S

生物&药学活性

物理化学性质&存储条件

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CDRI-1709S

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物理化学性质&存储条件

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