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首页-抗体药物偶连体和PROTACs-PROTAC-CDK2 degrader 37
CDK2 degrader 37

Chemical Structure : CDK2 degrader 37

CAS No.: 3030279-55-8

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CDK2 degrader 37

货号: PC-25360Not For Human Use, Lab Use Only.

CDK2 degrader 37 is a potent, orally bioavailable and selective degrader of CDK2 with DC50 of 17 nM in CCNE1nonamp TOV21G cell line, >100-fold selectivity over CDK1, and >500-fold selectivity over CDK9.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CDK2 degrader 37 is a potent, orally bioavailable and selective degrader of CDK2 with DC50 of 17 nM in CCNE1nonamp TOV21G cell line, >100-fold selectivity over CDK1, and >500-fold selectivity over CDK9.

物理化学性质&存储条件

分子量 852.90
分子式 C39H46F6N8O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[(3S,4R)-1-[[1-[4-(2,6-Dioxo-3-piperidyl)-2-fluoro-phenyl]-4-piperidyl]methyl]-3-fluoro-4-piperidyl]-3-fluoro-4-[[4-[(3S)-3-hydroxy-3-methyl-1-piperidyl]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzenesulfonamide

参考文献

1. Collier PN, et al. J Med Chem. 2025 Aug 20. doi: 10.1021/acs.jmedchem.5c01160.

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