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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Estrogen Receptor/ERR-CDD-1274
CDD-1274

Chemical Structure : CDD-1274

CAS No.:

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CDD-1274 (CDD1274)

货号: PC-25768Not For Human Use, Lab Use Only.

CDD-1274 is a small molecule degrader of wild type and mutant estrogen receptor with IC50 of 1 uM for ERα Y537S and D538G LBDs, induces WT and Y537S ERα degradation through the 26S proteasome pathway.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CDD-1274 is a small molecule degrader of wild type and mutant estrogen receptor with IC50 of 1 uM for ERα Y537S and D538G LBDs, induces WT and Y537S ERα degradation through the 26S proteasome pathway.
CDD-1274 blocks a subset of E2-induced genes at the transcriptional level.
CDD-1274 degrades WT ERα and constitutively active ERα mutants and blocks ER signaling in MCF-7 cells
CDD-1274 decreases levels of ERα and its targets in palbociclib-resistant WT and Y537S MCF-7 cells.

物理化学性质&存储条件

分子量 566.59
分子式 C29H34F4N2O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(3-(8-(((4-fluoro-5'-hydroxy-2'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)methyl)amino)bicyclo[4.1.1]octan-7-yl)-3-oxopropoxy)-N-methylpropanamide

参考文献

1. Devakrishnan AK, et al. NPJ Breast Cancer. 2025 Nov 12;11(1):125.

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