CD73 inhibitor XC-12

Chemical Structure : CD73 inhibitor XC-12

加入收藏

货号: PC-24682Not For Human Use, Lab Use Only.

CD73 inhibitor XC-12 is a potent, orally bioactive CD73 inhibitor with IC50 of 12.36 and 1.29 nM against both soluble and membrane-bound forms (hCD73).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CD73 inhibitor XC-12 is a potent, orally bioactive CD73 inhibitor with IC50 of 12.36 and 1.29 nM against both soluble and membrane-bound forms (hCD73).
XC-12 exhibits potent antiproliferative activity. orally bioavailable and significantly inhibited the tumor growth in the CT26 syngeneic mouse model (TGI: 74%) at a dose of 135 mg/kg.

物理化学性质&存储条件

分子量	460.37
分子式	C20H15F3N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-((1-(6-(2,4-Dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-oxo-2,3-dihydropyridazin-4-yl)pyrrolidin-3-yl)oxy)-2-(trifluoromethyl)benzonitrile

参考文献

1. Lifang Cen, et al. J Med Chem. 2025 May 23. doi: 10.1021/acs.jmedchem.5c00035.