CD38 inhibitor 16

Chemical Structure : CD38 inhibitor 16

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货号: PC-28503Not For Human Use, Lab Use Only.

CD38 inhibitor 16 is a potent, selective and brain-penetrant CD38 inhibitor with IC50 of 2.71 nM and 1.94 nM for mCD38 and hCD37 respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

CD38 inhibitor 16 is a potent, selective and brain-penetrant CD38 inhibitor with IC50 of 2.71 nM and 1.94 nM for mCD38 and hCD37 respectively.
CD38 inhibitor 16 shows no inhibitory activity across a panel of off-target NAD+-consuming enzymes, consisting of sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs).
CD38 inhibitor 16 (3-100 mg/kg, oral) demonstrated dose-dependent increases in NAD+ levels in brain and lung tissues of mice.

物理化学性质&存储条件

分子量	375.38
分子式	C16H14FN5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)-3-fluoro-6,7-dihydroimidazo[1,5-d]pyrido[2,3-f][1,4]oxazepine

参考文献

1. Hodges TR, et al. ACS Med Chem Lett. 2026 Sep 10;17(10):2160-2167.