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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-RAR/RXR-CD1530
CD1530

Chemical Structure : CD1530

CAS No.: 107430-66-0

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CD1530 (CD-1530)

货号: PC-70289Not For Human Use, Lab Use Only.

CD1530 is a potent and selective RARγ receptor agonist with Ki of 150 nM, >10-fold less potent for RARβ and RARα.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CD1530 is a potent and selective RARγ receptor agonist with Ki of 150 nM, >10-fold less potent for RARβ and RARα.
CD1530  also is a potent an inhibitor of CYP26A1 as ketoconazole with IC50 of 530 nM.

物理化学性质&存储条件

分子量 398.49
分子式 C27H26O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(6-Hydroxy-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoic acid

参考文献

1. Tang XH, et al. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8907-12.

2. Thatcher JE, et al. Mol Pharmacol. 2011 Aug;80(2):228-39.

3. Duprey-Díaz MV, et al. PLoS One. 2016 Sep 9;11(9):e0162626.

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