欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-GPCR-Adrenergic Receptor-CC10137
CC10137

Chemical Structure : CC10137

CAS No.: 3061967-46-9

加入收藏

CC10137 (CC-10137)

货号: PC-27359Not For Human Use, Lab Use Only.

CC10137 is a potent, orally bioavailable, peripherally restricted α2A-adrenergic receptor (α2AAR) agonist with Ki of 6.0 nM, exhibits potent α2AAR agonist activity (EC50=13.1 nM) in HEK293T cells co-transfected with α2AAR and Gα15 plasmids.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CC10137 is a potent, orally bioavailable, peripherally restricted α2A-adrenergic receptor (α2AAR) agonist with Ki of 6.0 nM, exhibits potent α2AAR agonist activity (EC50=13.1 nM) in HEK293T cells co-transfected with α2AAR and Gα15 plasmids.
CC10137 shows a stronger binder for α2AAR than clonidine or tizanidine.
CC10137 does not induce sedation, hypotension, hypothermia, and impairment of the tail-flick reflexes in mice.
CC10137 does not impair the spinal nociceptive reflex.
CC10137 demonstrates α2AR-dependent efficacy and broad synergistic potential in a neuropathic pain model.
CC10137 demonstrated dose-dependent, synergistic, and long-lasting anti-allodynia in cancer pain models.

物理化学性质&存储条件

分子量 355.46
分子式 C19H21N3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(3-((2,3-dimethylphenyl)(1H-imidazol-4-yl)methyl)phenyl)methanesulfonamide

参考文献

1. Cheng Z, et al. Cell Rep Med. 2026 Jul 21;7(7):102864.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: