CBI-3 | BAX inhibitor | Probechem Biochemicals

Chemical Structure : CBI-3

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CBI-3 (Covalent BAX inhibitor 3)

货号: PC-27910Not For Human Use, Lab Use Only.

CBI-3 (Covalent BAX inhibitor 3) is a covalent BAX inhibitor, protects cells from BAX-dependent apoptosis.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

CBI-3 (Covalent BAX inhibitor 3) is a covalent BAX inhibitor, protects cells from BAX-dependent apoptosis.
CBI-3 covalently derivatized BAX WT in vitro and showed superior potency in inhibiting BAX-mediated apoptosis in HCT116 Bak−/− cells compared to WX-02-16.
CBI-3 also protected primary DRG neurons from ABT-737-induced apoptosis, as reflected by cell viability and caspase-3/7 activation assays.
CBI-3 protects against murine liver failure and human MN degeneration.
CBI-3 protects WT liver and human induced pluripotent stem cell (hiPS cell)-derived motor neurons (MNs).

物理化学性质&存储条件

分子量	465.46
分子式	C25H21F2N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,3S)-2-acryloyl-N-cyclopropyl-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide

参考文献

1. Shi P, et al. Nat Chem Biol. 2026 Aug 28. doi: 10.1038/s41589-026-02297-9.

CBI-3 (Covalent BAX inhibitor 3)

生物&药学活性

物理化学性质&存储条件

参考文献

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CBI-3 (Covalent BAX inhibitor 3)

生物&药学活性

物理化学性质&存储条件

参考文献

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