CAS-010 (CAS-13312-010) | USP28 inhibitor | Probechem Biochemicals

Chemical Structure : CAS-010

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CAS-010 (CAS010, CAS-13312-010)

货号: PC-25366Not For Human Use, Lab Use Only.

CAS-010 (CAS-13312-010) is a potent, selective and ubiquitin-competitive inhibitor of USP28 with IC50 of 4.2 nM in UbRho assays, disrupts the 53BP1-USP28 interaction and reduces p53 target gene transactivation.

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250 mg		Get quote

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生物&药学活性

CAS-010 (CAS-13312-010) is a potent, selective and ubiquitin-competitive inhibitor of USP28 with IC50 of 4.2 nM in UbRho assays, disrupts the 53BP1-USP28 interaction and reduces p53 target gene transactivation.
CAS-010 inhibits recombinant full-length (FL) USP28 with single-digit nanomolar potency (IC50=2.2 nM).
CAS-010 inhibits closely related USP25 with IC50 of 75 nM (USP25 CD) and 51 nM (USP25 FL).
CAS-010 blocks ABP labeling of USP28 and USP25 in a dose dependent manner in ABPP-MS experiment in HCT116 lysate, but not binding the other 57 DUBs de tected.
CAS-010 recapitulates the effects of USP28 genetic loss, both with respect to viability and p53 relationship.
CAS-010 attenuates p53 gene transactivation.
CAS-010 significantly decreases 53BP1-USP28 PLA foci in both cell lines and conditions in RPE-1 and U2OS cells, both with and without IR-induced DNA damage.

物理化学性质&存储条件

分子量	448.63
分子式	C26H32N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(8-azabicyclo[3.2.1]octan-3-yl)phenethyl)-3-amino-6-propylthieno[2,3-b]pyridine-2-carboxamide

参考文献

1. Bratt AS, et al. Cell Chem Biol. 2025 Sep 1:S2451-9456(25)00232-6.

CAS-010 (CAS010, CAS-13312-010)

生物&药学活性

物理化学性质&存储条件

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CAS-010 (CAS010, CAS-13312-010)

生物&药学活性

物理化学性质&存储条件

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