Chemical Structure : CARD9 inhibitor Compound 6
CAS No.:
312621-11-7
CARD9 inhibitor Compound 6
货号: PC-25983Not For Human Use, Lab Use Only.
CARD9 inhibitor Compound 6 is a potent, specific CARD9 inhibitor with SPR Kd of 120 nM (human CARD9), and IC50 of 0.33 uM in TR-FRET assays, blocks CARD9-dependent NF-κB activation and cytokine release.
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纯度 & COA & 质检文件 纯度:
>98% (HPLC)
生物&药学活性
CARD9 inhibitor Compound 6 is a potent, specific CARD9 inhibitor with SPR Kd of 120 nM (human CARD9), and IC50 of 0.33 uM in TR-FRET assays, blocks CARD9-dependent NF-κB activation and cytokine release.
CARD9 inhibitor Compound 6 selectively suppressed the release of interleukin (IL)-1β, IL-6, and TNF via the Dectin-1/CARD9 axis in THP-1 cells, while TLR2/6-mediated cytokine secretion was unimpaired.
CARD9 inhibitor Compound 6 modifies cellular responses by acting directly at the level of CARD9 to prevent NF-κB signaling in primary human cells.
CARD9 inhibitor Compound 6 has SPR kd of 250 nM for humanized murine CARD9 (mCARD9).
CARD9 inhibitor Compound 6 restricts inflammatory responses in a mouse model of acute fungal infection.
物理化学性质&存储条件
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分子量
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465.60
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分子式
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C30H31N3O2
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外观性状
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Solid
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CAS No.
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储存条件
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- 固体粉末
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-20°C 12 个月; 4°C 6 个月
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- 配置液
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-80°C 6 个月; -20°C 6 个月
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-10-benzoyl-11-(4-(dimethylamino)phenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
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参考文献
1. Rush JS, et al. Cell. 2026 Jan 16:S0092-8674(25)01426-6.
