C607-0736

Chemical Structure : C607-0736

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货号: PC-26096Not For Human Use, Lab Use Only.

C607-0736 is a specific small molecule inhibitor of outer membrane protein V (OmpV) withSPR KD of 0.15 uM, disrupts the virulence functions of V. cholerae OmpV.

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生物&药学活性

C607-0736 is a specific small molecule inhibitor of outer membrane protein V (OmpV) withSPR KD of 0.15 uM, disrupts the virulence functions of V. cholerae OmpV.
C607-0736 significantly inhibited the adherence ability of V. cholerae WT strain, but not the ΔompV strain.
C607-0736 is a broad-spectrum inhibitor of infection caused by pandemic V. cholerae.
C607-0736 significantly inhibited V. cholerae colonization in the small intestine only at concentrations of 10 and 20 mg/kg.
C607-0736 widely inhibits the colonization ability of different pandemic V. cholerae strains by blocking the function of OmpV, including pandemic V. cholerae O1 strains (EL2382, EL2281, and EL1605) and O139 strains (strains MO45, 0820, and 0539).

物理化学性质&存储条件

分子量	430.50
分子式	C26H26N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-((furan-2-ylmethyl)(isopropyl)amino)ethyl)-1-oxo-4-phenyl-1H-isochromene-3-carboxamide

参考文献

1. Liu R, et al. Nat Commun. 2025 Dec 11. doi: 10.1038/s41467-025-67532-8.

2. Patent CN119302946 A 2025-01-14.

C607-0736

生物&药学活性

物理化学性质&存储条件

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C607-0736

生物&药学活性

物理化学性质&存储条件

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