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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ras-C4-180
C4-180

Chemical Structure : C4-180

CAS No.:

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C4-180

货号: PC-25585Not For Human Use, Lab Use Only.

C4-180 is a potent, specific small molecule pan-RALGEF (Ras-like small GTPases exchange factors) inhibitor, specifically inhbits RAL but not MAPK/AKT signaling, impairs the interaction of RALGEFs with RAS.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

C4-180 is a potent, specific small molecule pan-RALGEF (Ras-like small GTPases exchange factors) inhibitor, specifically inhbits RAL but not MAPK/AKT signaling, impairs the interaction of RALGEFs with RAS.
C4-180 directly binds RALGDS with KD value of 2.55 uM in MST assays.
C4-180 acts on both RALGDS and RGL2.
C4-180 inhibits soft agar growth of RAS driven tumor cells with IC50 of <500 nM.
C4-180 specifically suppress RAS signaling through the RAL pathway.
C4-180 (40mg/kg) inhibits tumor formation and metastasis in pancreatic cancer models, with no detectable toxicity.

物理化学性质&存储条件

分子量 436.55
分子式 C24H25FN4OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(((3-fluorobenzyl)amino)methyl)-N-(3-methoxybenzyl)-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine

参考文献

1. Donninger H, et al. J Biol Chem. 2025 Oct 8:110809.

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