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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Aminopeptidase-C301-9181
C301-9181

Chemical Structure : C301-9181

CAS No.: 933012-29-4

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C301-9181

货号: PC-28679Not For Human Use, Lab Use Only.

C301-9181 is a small-molecule inhibitor of aminopeptidase-like 1 (NPEPL1) that directly binds NPEPL1 with micromolar affinity (KD=2.77 uM), suppresses NPEPL1 expression and aminopeptidase activity, and exhibits anti-HCC efficacy in vitro and in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

C301-9181 is a small-molecule inhibitor of aminopeptidase-like 1 (NPEPL1) that directly binds NPEPL1 with micromolar affinity (KD=2.77 uM), suppresses NPEPL1 expression and aminopeptidase activity, and exhibits anti-HCC efficacy in vitro and in vivo.

物理化学性质&存储条件

分子量 375.45
分子式 C20H17N5OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-((5,6-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)thio)phenyl)benzamide

参考文献

1. Yu Qin, et al. Targeting SRF-activated aminopeptidase NPEPL1 with a novel small-molecule inhibitor offers a potential therapeutic strategy for hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research

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