Butyrolactone 3 | GCN5 inhibitor | Probechem Biochemicals

Chemical Structure : Butyrolactone 3

CAS No.: 778649-18-6

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Butyrolactone 3 (MB-3, γ-butyrolactone)

货号: PC-26970Not For Human Use, Lab Use Only.

Butyrolactone 3 (MB-3) is a specific, cell-permeable small-molecule inhibitor of histone acetyltransferase GCN5 with IC50 of 100 uM.

规格	价格	库存
5 mg	￥2180	In stock
10 mg	￥3480	In stock
25 mg	￥5480	In stock
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100 mg		Get quote

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生物&药学活性

Butyrolactone 3 (MB-3) is a specific, cell-permeable small-molecule inhibitor of histone acetyltransferase GCN5 with IC50 of 100 uM.
Butyrolactone 3 (MB-3) shows high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3.
Butyrolactone 3 (MB-3) decreased E2A-PBX1 acetylation and E2A-PBX1 protein levels in leukemic cells.
Butyrolactone 3 (MB-3) also is a chemical inhibitor of the histone acetyltransferase in Arabidopsis.

物理化学性质&存储条件

分子量	184.19
分子式	C9H12O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	rel-(2S,3R)-4-Methylene-5-oxo-2-propyltetrahydrofuran-3-carboxylic acid

参考文献

1. Holmlund T, et al. Leukemia. 2013 Mar;27(3):578-85.

2. Xu H, et al. Sci Rep. 2020 Feb 4;10(1):1817.

3. Biel M,et al. Angew Chem Int Ed Engl. 2004 Jul 26;43(30):3974-6.

4. Aquea F, et al. Biochem Biophys Res Commun. 2017 Jan 29;483(1):664-668.

Butyrolactone 3 (MB-3, γ-butyrolactone)

生物&药学活性

物理化学性质&存储条件

参考文献

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Butyrolactone 3 (MB-3, γ-butyrolactone)

生物&药学活性

物理化学性质&存储条件

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