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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Carbonic Anhydrase-Brinzolamide
Brinzolamide

Chemical Structure : Brinzolamide

CAS No.: 138890-62-7

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Brinzolamide (AL-4862, AL4862)

货号: PC-24455Not For Human Use, Lab Use Only.

Brinzolamide (AL-4862) is a potent, selective carbonic anhydrase II (CA II) inhibitor with IC50 of 3.2 nM, reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion.

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25 mg ￥480 In stock
50 mg ￥680 In stock
100 mg ￥1080 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Brinzolamide (AL-4862) is a potent, selective carbonic anhydrase II (CA II) inhibitor with IC50 of 3.2 nM, reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion.

物理化学性质&存储条件

分子量 383.50
分子式 C12H21N3O5S3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide, (4R)-

参考文献

1. Vatsala Naageshwaran, et al. J Pharm Sci. 2021 Jan;110(1):529-535.

2. Ilies M, et al. Bioorg Med Chem. 2000 Aug;8(8):2145-55.

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