Brigatinib (AP-26113) | ALK inhibitor | Probechem Biochemicals

Chemical Structure : Brigatinib

CAS No.: 1197953-54-0

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Brigatinib (AP-26113, AP26113)

货号: PC-43260Not For Human Use, Lab Use Only.

Brigatinib (AP-26113, AP26113) is a potent, selective, second generation ALK inhibitor with IC50 of 0.62 nM, exhibits about fivefold greater potency in vitro compared with crizotinib.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
250 mg		Get quote

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生物&药学活性

Brigatinib (AP-26113, AP26113) is a potent, selective, second generation ALK inhibitor with IC50 of 0.62 nM, exhibits about fivefold greater potency in vitro compared with crizotinib.
Brigatinib (AP-26113, AP26113) shows high activity against both sensitive and resistant H3122 cells, decreasing cell growth, suppressing ALK phosphorylation, and inducing apoptosis.
Brigatinib (AP-26113, AP26113) is also active in Ba/F3 cells expressing either native or mutant EML4-ALK with IC50 of 10 and 24 nM, respectively.
Brigatinib (AP-26113, AP26113) demonstrates promising activity in crizotinib resistant.

物理化学性质&存储条件

分子量	584.0924
分子式	C29H39ClN7O2P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in Ethanol
Chemical Name/SMILES	2,4-Pyrimidinediamine, 5-chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-

参考文献

1. Katayama R, et al. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7535-40.

2. Ceccon M, et al. Mol Cancer Res. 2013 Feb;11(2):122-32.

3. Ceccon M, et al. Mol Cancer Res. 2015 Apr;13(4):775-83.

4. Fontana D, et al. Cancer Med. 2015 Jul;4(7):953-65.

Brigatinib (AP-26113, AP26113)

生物&药学活性

物理化学性质&存储条件

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Brigatinib (AP-26113, AP26113)

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