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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-Brevilin A
Brevilin A

Chemical Structure : Brevilin A

CAS No.: 16503-32-5

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Brevilin A

货号: PC-25382Not For Human Use, Lab Use Only.

Brevilin A is an orally active STAT3/JAK inhibitor with IC50 of 10.6 uM (STAT3), exerts potent anti-inflammatory, antitumor, immunosuppressive, and anti-liver fibrosis effects, also reduces protein levels of LRRC15 in RA fibroblast-like synoviocytes (RA-FLSs).

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5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Brevilin A is an orally active STAT3/JAK inhibitor with IC50 of 10.6 uM (STAT3), exerts potent anti-inflammatory, antitumor, immunosuppressive, and anti-liver fibrosis effects, also reduces protein levels of LRRC15 in RA fibroblast-like synoviocytes (RA-FLSs).
Brevilin A is reported to regulate the SIRT1/Nrf2/GPX4 signaling pathway to inhibit the production of MMP1 and MMP3 and alleviate joint damage in mice.
Brevilin A effectively alleviates LPS-induced lung damage, inflammatory infiltration, and the production of proinflammatory cytokines in LPS-induced acute lung injury.
Brevilin A significantly reduced the protein levels of LRRC15 in TNF-α-induced RA fibroblast-like synoviocytes (RA-FLSs).
Brevilin A significantly inhibited STAT3 phosphorylation without affecting total STAT3 protein levels
Brevilin A ameliorates arthritis symptoms in CIA rats.

物理化学性质&存储条件

分子量 346.42
分子式 C20H26O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3S,3aR,4S,4aR,7aR,8R,9aR)-3,4a,8-Trimethyl-2,5-dioxo-2,3,3a,4,4a,5,7a,8,9,9a-decahydroazuleno[6,5-b]furan-4-yl (Z)-2-methylbut-2-enoate

参考文献

1. Chen X, et al. PLoS One. 2013 May 21;8(5):e63697.

2. Qiao Z, et al. Arthritis Res Ther. 2025 Aug 20;27(1):167.

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