Bigelovin

Chemical Structure : Bigelovin

CAS No.: 3668-14-2

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货号: PC-24606Not For Human Use, Lab Use Only.

Bigelovin is a sesquiterpene lactone isolated from Inula hupehensis I and selective RXR agonist (EC50=4.9 uM), binds to RXRα-LBD with Kd of 8.7 uM.

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5 mg	￥1880	In stock
10 mg	￥2980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Bigelovin is a sesquiterpene lactone isolated from Inula hupehensis I and selective RXR agonist (EC50=4.9 uM), binds to RXRα-LBD with Kd of 8.7 uM.
Bigelovin exerts inhibitory effects and triggers proteolysis of E2F1 in multiple myeloma cells.
Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells.
Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species.
Bigelovin efficiently inhibit a panel of cancer cells growth, including A549 (lung cancer), SGC-7901 (gastric cancer), BEL-7402 (liver cancer), U251 (glioma), B16 (murine melanoma), K562 (leukemia), and U937 (leukemia).

物理化学性质&存储条件

分子量	304.34
分子式	C17H20O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Azuleno[6,5-b]furan-2,5-dione, 4-(acetyloxy)-3,3a,4,4a,7a,8,9,9a-octahydro-4a,8-dimethyl-3-methylene-, (3aR,4S,4aR,7aR,8R,9aS)-

参考文献

1. Li M, et al. Sci Rep. 2017 Feb 9;7:42176.

2. Zhang HH, et al. Acta Pharmacol Sin. 2015 Apr;36(4):507-16.

3. Zhang H, et al. J Mol Biol. 2011 Mar 18;407(1):13-20.

Bigelovin

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Bigelovin

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