Bexicaserin (LP352) | 5-HT2C agonist | Probechem Biochemicals

Chemical Structure : Bexicaserin

CAS No.: 2035818-24-5

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货号: PC-21971Not For Human Use, Lab Use Only.

Bexicaserin (LP352) is a potent, highly selective, oral and centrally acting 5-HT2C receptor agonist with EC50 of 42 nM (Emax=112%), and Ki of 39 nM.

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Bexicaserin (LP352) is a potent, highly selective, oral and centrally acting 5-HT2C receptor agonist with EC50 of 42 nM (Emax=112%), and Ki of 39 nM.

Bexicaserin (LP352) shows no detected activity at the 5-HT2B and 5-HT2A receptor subtypes.

Bexicaserin (LP352) displays excellent oral bioavailability, good central nervous system partitioning, and decreased renal clearance in vivo.

Bexicaserin (LP352) also is a potent inhibitor of acute refeeding in the fasted rat, suggesting on-target effects.

分子量	295.33
分子式	C15H19F2N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R)-N-(2,2-difluoroethyl)-3-methyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4,6,8(13)-triene-5-carboxamide

1. Ren A, et al. J Med Chem. 2025 May 14. doi: 10.1021/acs.jmedchem.4c02923.