Beta-caryophyllene (β-Caryophyllene, (E)-BCP) | CB2 agonist

Chemical Structure : Beta-caryophyllene

CAS No.: 87-44-5

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Beta-caryophyllene (β-Caryophyllene, (-)-(E)-Caryophyllene, (−)-β-caryophyllene, (−)-trans-Caryophyllene)

货号: PC-28081Not For Human Use, Lab Use Only.

Beta-caryophyllene (β-Caryophyllene, (E)-BCP) is a high affinity, selective agonist of cannabinoid receptor type 2 (CB2) with Ki of 115 nM, also possesses significant anticancer activities, affecting growth and proliferation of numerous cancer cells.

规格	价格	库存
500 mg	￥350	In stock
1 g	￥550	In stock
5 g	￥1250	In stock
10 g		Get quote

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生物&药学活性

Beta-caryophyllene (β-Caryophyllene, (E)-BCP) is a high affinity, selective agonist of cannabinoid receptor type 2 (CB2) with Ki of 115 nM, also possesses significant anticancer activities, affecting growth and proliferation of numerous cancer cells.
Beta-caryophyllene (β-Caryophyllene, (E)-BCP) inhibits adenylate cylcase, leads to intracellular calcium transients and weakly activates the mitogen-activated kinases Erk1/2 and p38 in primary human monocytes.
Beta-caryophyllene (β-Caryophyllene, (E)-BCP) (500 nM) inhibits lipopolysaccharide (LPS)-induced proinflammatory cytokine expression in peripheral blood and attenuates LPS-stimulated Erk1/2 and JNK1/2 phosphorylation in monocytes.
Beta-caryophyllene (β-Caryophyllene, (E)-BCP) (5 mg/kg) strongly reduces the carrageenan-induced inflammatory response in wild-type mice but not in mice lacking CB(2) receptors.
Beta-caryophyllene modulates expression of stress response genes and mediates longevity in Caenorhabditis elegans.

物理化学性质&存储条件

分子量	204.36
分子式	C15H24
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,9S,E)-4,11,11-Trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene

参考文献

1. Javed H, et al. Front Neurosci. 2016 Aug 2;10:321.

2. Gertsch J, et al. Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9099-104.

3. da Silva SL, et al. Eur J Pharmacol. 2007 Dec 8;576(1-3):180-8.

4. Fidyt K, et al. Cancer Med. 2016 Oct;5(10):3007-3017.

Beta-caryophyllene (β-Caryophyllene, (-)-(E)-Caryophyllene, (−)-β-caryophyllene, (−)-trans-Caryophyllene)

生物&药学活性

物理化学性质&存储条件

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Beta-caryophyllene (β-Caryophyllene, (-)-(E)-Caryophyllene, (−)-β-caryophyllene, (−)-trans-Caryophyllene)

生物&药学活性

物理化学性质&存储条件

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