Bazedoxifene | SERM | Probechem Biochemicals

Chemical Structure : Bazedoxifene

CAS No.: 198481-32-2

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Bazedoxifene (WAY-140424, TSE-424, TSE424)

货号: PC-24541Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

Bazedoxifene (TSE-424, WAY-140424) is a potent, orally bioavailable, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM) with IC50 of 23 nM and 99 nM for ERα and ERβ, respectively.
Bazedoxifene (TSE-424, WAY-140424) is a high-affinity ligand for ERα (and subsequently for ERβ) with a Ki of 0.1 nM (0.3 nM for ERβ) and no crossover binding to the other members of the steroid/retinoid family of nuclear receptors (e.g., androgen, progesterone, vitamin D, retinoid, rexinoid, etc.).
Bazedoxifene inhibits 17β-estradiol-stimulated proliferation in MCF-7 cells with IC50 of 0.19 nM.
Bazedoxifene reduces raloxifene-stimulated endometrial luminal epithelial cell and myometrial cell hypertrophy.

物理化学性质&存储条件

分子量	470.61
分子式	C30H34N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol

参考文献

1. Komm BS, et al. Ann N Y Acad Sci. 2001 Dec;949:317-26.

2. Ronkin S, et al. Obstet Gynecol. 2005 Jun;105(6):1397-404.

3. Komm BS, et al. Endocrinology. 2005 Sep;146(9):3999-4008.

Bazedoxifene (WAY-140424, TSE-424, TSE424)

生物&药学活性

物理化学性质&存储条件

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Bazedoxifene (WAY-140424, TSE-424, TSE424)

生物&药学活性

物理化学性质&存储条件

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