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首页-小分子抑制剂&激动剂-GPCR-Cannabinoid Receptor-Bay 59-3074
Bay 59-3074

Chemical Structure : Bay 59-3074

CAS No.: 406205-74-1

Bay 59-3074 (Bay59-3074;Bay-59-3074)

货号: PC-42171Not For Human Use, Lab Use Only.

Bay 59-3074 is a potent, selective cannabinoid CB1/CB2 receptor partial agonist with Ki of 48.3, and 45.5 nM for human CB1 and human CB2 receptors, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Bay 59-3074 is a potent, selective cannabinoid CB1/CB2 receptor partial agonist with Ki of 48.3, and 45.5 nM for human CB1 and human CB2 receptors, respectively.
Bay 59-3074 displays antihyperalgesic and antiallodynic effects against thermal or mechanical stimuli in rat models of chronic neuropathic; orally acitve.

物理化学性质&存储条件

分子量 453.3555
分子式 C18H13F6NO4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 34 mg/mL

Chemical Name/SMILES

1-Butanesulfonic acid, 4,4,4-trifluoro-, 3-[2-cyano-3-(trifluoromethyl)phenoxy]phenyl ester

参考文献

1. De Vry J, et al. J Pharmacol Exp Ther. 2004 Aug;310(2):620-32.

2. De Vry J, et al. Eur J Pharmacol. 2004 Nov 28;505(1-3):127-33.

3. Teng H, et al. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5999-6002.

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