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首页-抗体和重组蛋白-Other Fusion Proteins-Batiraxcept
Batiraxcept

Chemical Structure : Batiraxcept

CAS No.: 2268717-61-7

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Batiraxcept (AVB-S6-500, AVB-500)

货号: PC-38856Not For Human Use, Lab Use Only.

Batiraxcept (AVB‐S6‐500, AVB-500) is a first-in-class Fc fusion protein of the extracellular domain of AXL that binds the GAS6 ligand thereby inhibiting AXL signaling.

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1 mg ￥4580 In stock
2 mg ￥7280 In stock
5 mg ￥13800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Batiraxcept (AVB‐S6‐500, AVB-500) is a first-in-class Fc fusion protein of the extracellular domain of AXL that binds the GAS6 ligand thereby inhibiting AXL signaling.
    Batiraxcept (AVB‐S6‐500, AVB-500) neutralized growth arrest-specific 6 (GAS6) protein and effectively inhibited AXL signaling in preclinical cancer models.
    ABatiraxcept (AVB‐S6‐500, AVB-500) binds GAS6 with low femtomolar range affinity to effectively bind GAS6 and eliminate its ability to stimulate the AXL pathway.
    Human tyrosine-protein kinase receptor UFO (AXL oncogene) fragment (8-202, 1-195 in the current sequence), variant (G14>S7, A54>V47, D69>G62, V74>A67, G109>R102), fused via peptidyl linker (196GGGGS200) to a human immunoglobulin G1 Fc fragment (201-426, C-terminal Lys residue deleted), dimer, glycosylated, produced in Chinese hamster ovary (CHO) cells.

    物理化学性质&存储条件

    分子量
    分子式
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    [AXL (AXL receptor tyrosine kinase, ARK, JTK11, Tyro7, UFO)]2-IGHG1 Fc (Fragment constant)

    参考文献

    1. Bonifacio L, et al. Clin Transl Sci. 2020 Jan;13(1):204-211.

    2. Mullen MM, et al. Mol Cancer Res. 2022 Feb;20(2):265-279.

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