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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Keap1-Nrf2-Bardoxolone
Bardoxolone

Chemical Structure : Bardoxolone

CAS No.: 218600-44-3

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Bardoxolone (CDDO, RTA401 ,RTA-401)

货号: PC-25722Not For Human Use, Lab Use Only.

Bardoxolone (RTA401, CDDO) is a covalent, orally active activator of NRF2, also inhibits SARS-CoV-2 3CL protease (EC50=0.43 uM), also inhibits necroptosis in HT-29 cells by blocking necrosome formation through inhibiting phosphorylation of RIPK1 and RIPK3.

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10 mg ￥780 In stock
50 mg ￥1480 In stock
100 mg ￥2480 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Bardoxolone (RTA401, CDDO) is a covalent, orally active activator of NRF2, also inhibits SARS-CoV-2 3CL protease (EC50=0.43 uM), also inhibits necroptosis in HT-29 cells by blocking necrosome formation through inhibiting phosphorylation of RIPK1 and RIPK3.

物理化学性质&存储条件

分子量 491.67
分子式 C31H41NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-Cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicene-4a(2H)-carboxylic acid

参考文献

1. Sun Q, et al. Signal Transduct Target Ther. 2021 May 29;6(1):212.

2. Wang Y, et al. Eur J Med Chem. 2021 Feb 15;212:113030.

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