BW710 | FGFR2 inhibitor | Probechem Biochemicals

Chemical Structure : BW710

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BW710 (BW-710)

货号: PC-24068Not For Human Use, Lab Use Only.

BW710 is a potent, selective, covalent and orally bioavailable FGFR2 inhibitor, potently inhibits the proliferation of BaF3-FGFR2 cells with IC50 of 2.8 nM.

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生物&药学活性

BW710 is a potent, selective, covalent and orally bioavailable FGFR2 inhibitor, potently inhibits the proliferation of BaF3-FGFR2 cells with IC50 of 2.8 nM.
BW710 covalently binds to FGFR2 kinase P-loop residue Cys491.
BW710 is much less active against BaF3-FGFR1 and parental BaF3 cells with IC50 values of >1000 nM.
BW710 completely abolished FGFR2 enzymatic activity and was selective against other 75 tyrosine kinases including FGFR1, FGFR3, and FGFR4 at 1 μM.
BW710 potently suppressed the FGFR2 signaling and selectively inhibited FGFR2-driven cancer cell proliferation.

物理化学性质&存储条件

分子量	532.64
分子式	C28H29FN6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	NC1=C2C(N(C)C(C3=C(F)C=C(NC(C(C)=C)=O)C=C3)=C2C4=CC=C(S5(CCCCCN=5)=O)C=C4)=NC=N1

参考文献

1. Bowen Yang, et al. Eur J Med Chem. 2025 Feb 1:287:117339.

BW710 (BW-710)

生物&药学活性

物理化学性质&存储条件

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BW710 (BW-710)

生物&药学活性

物理化学性质&存储条件

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