BT317 | LonP1 inhibitor | Probechem Biochemicals

Chemical Structure : BT317

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BT317 (BT 317)

货号: PC-20757Not For Human Use, Lab Use Only.

BT317 is a small molecule dual inhibitor of mitochondrial Lon Peptidase 1 (LonP1) and CT-L proteasome, subsequently induces ROS accumulation and autophagy-dependent cell death in high-grade IDH1 mutated astrocytoma lines.

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生物&药学活性

BT317 is a small molecule dual inhibitor of mitochondrial Lon Peptidase 1 (LonP1) and CT-L proteasome, subsequently induces ROS accumulation and autophagy-dependent cell death in high-grade IDH1 mutated astrocytoma lines.
BT317 inhibits LonP1 protease activity with IC50 of 58.15 uM.
BT317 exhibits synergy with temozolomide in autophagy-dependent cell death in IDH1 mutant malignant astrocytoma.
BT317 is selective to the tumor microenvironment and demonstrated therapeutic efficacy both as a single agent and in combination TMZ in IDH mutant astrocytoma models.

物理化学性质&存储条件

分子量	315.71
分子式	C16H10ClNO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-chloro-N-(4-hydroxyphenyl)-2-oxo-2H-chromene-3-carboxamide

参考文献

1. Douglas C, et al. bioRxiv. 2023 Apr 17:2023.04.13.536816.

BT317 (BT 317)

生物&药学活性

物理化学性质&存储条件

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BT317 (BT 317)

生物&药学活性

物理化学性质&存储条件

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