BT1137 | Shroom3-Rock interaction inhibitor | Probechem Biochemicals

Chemical Structure : BT1137

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BT1137 (Compound D4G)

货号: PC-26245Not For Human Use, Lab Use Only.

BT1137 (D4G) is a specific small molecule Shroom3-Rock interaction inhibitor, inhibits ROCK1 and ROCK2 nearly identically.

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生物&药学活性

BT1137 (D4G) is a specific small molecule Shroom3-Rock interaction inhibitor, inhibits ROCK1 and ROCK2 nearly identically.
BT1137 (D4G) showed significant inhibition of profibrotic marker and cytokine transcripts in IMCD cells.
BT1137 (D4G) significantly inhibited 3T3 proliferation, with potent reduction in pMypt1 and reduced markers of Wnt-signaling by qPCR in WT-Sh3-IMCDs.
BT1137 (D4G) ameliorated TIF progression in Tubular-Specific WT-Sh3 overexpression mice.

物理化学性质&存储条件

分子量	398.30
分子式	C18H15BF3KN2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	potassium trifluoro(4-(2-thioxo-1,2,3,4,5,6-hexahydrobenzo[h]quinazolin-4-yl)phenyl)borate

参考文献

1. Reghuvaran A, et al. Nat Commun. 2025 Dec 30. doi: 10.1038/s41467-025-67854-7.

BT1137 (Compound D4G)

生物&药学活性

物理化学性质&存储条件

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BT1137 (Compound D4G)

生物&药学活性

物理化学性质&存储条件

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