BSH inhibitor GR-7 (Gut restricted-7) | BSH inhibitor

Chemical Structure : BSH inhibitor GR-7

CAS No.: 2553218-46-3

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BSH inhibitor GR-7 (Gut-restricted 7)

货号: PC-27803Not For Human Use, Lab Use Only.

BSH inhibitor GR-7 (Gut restricted-7) is a potent, specific, covalent inhibitor of gut bacterial bile salt hydrolase (BSH) with IC50 of 237-1070 nM.

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10 mg	￥4580	In stock
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生物&药学活性

BSH inhibitor GR-7 (Gut restricted-7) is a potent, specific, covalent inhibitor of gut bacterial bile salt hydrolase (BSH) with IC50 of 237-1070 nM.
GR-7 selectively labels the B. theta BSH at Cys2.
GR-7 displays minimal off-target effects, does not affect farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor 1 (TGR5), shows limited off-target activity against other bacterial proteins or mammalian proteins in intestinal cells.
GR-7 (10 uM) inhibits BSHs in bacterial culture.
GR-7 can inhibit gut bacterial BSH activity and modulate the bile acid pool in vivo while not significantly affecting the gut bacterial community.
GR-7 reduces ursodeoxycholic acid (UDCA) level and GLP-1 production in mice fed with normal chow or a high-fat diet.
GR-7 markedly reduced hepatic steatosis and inflammation in diet induced mouse model of steatohepatitis.

物理化学性质&存储条件

分子量	510.64
分子式	C25H40FNaO6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium (3R,5R,7R,8R,9S,10S,13R,14S,17R)-17-((R)-6-fluoro-5-oxohexan-2-yl)-7-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl sulfate

参考文献

1. Arijit A Adhikari, et al. Nat Chem Biol. 2020 Mar;16(3):318-326.

2. Wei W, et al. Mol Metab. 2026 Aug 18:102430.

3. Lv J, et al. Gut Microbes. 2026 Dec 31;18(1):2668127.

BSH inhibitor GR-7 (Gut-restricted 7)

生物&药学活性

物理化学性质&存储条件

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BSH inhibitor GR-7 (Gut-restricted 7)

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物理化学性质&存储条件

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