BRL54443 | 5-HT1E/1F agonist | Probechem Biochemicals

Chemical Structure : BRL54443

CAS No.: 57477-39-1

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BRL54443 (BRL 54443, BRL-54443)

货号: PC-43401Not For Human Use, Lab Use Only.

BRL54443 is a potent, releative selective 5-HT1E/1F agonist with Ki of 2/1 nM, respectively.

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10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
250 mg		Get quote

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生物&药学活性

BRL54443 is a potent, releative selective 5-HT1E/1F agonist with Ki of 2/1 nM, respectively.
BRL54443 shows low affinity for other receptors 5-HT1A (63 nM), 5-HT1B (126 nM), 5-HT1D (63 nM), 5-HT2A (1259 nM), 5-HT2B (100 nM), 5-HT2C (316 nM), 5-HT6 (>10,000 nM), 5-HT7 (>10,000 nM), D2 (501 nM), D3 (631 nM), and α1B-adrenoceptors (1259 nM).
BRL54443 selectively stimulates 5-HT1E receptors and potently inhibits forskolin-dependent cAMP production with IC50 of 14 nM in DG membranes.
BRL54443 significantly reduces formalin-induced flinching in rats.

物理化学性质&存储条件

分子量	230.3055
分子式	C14H18N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 51 mg/mL
Chemical Name/SMILES	1H-Indol-5-ol, 3-(1-methyl-4-piperidinyl)-

参考文献

1. Klein MT, et al. J Pharmacol Exp Ther. 2011 Jun;337(3):860-7.

2. Klein MT,et al. Br J Pharmacol. 2012 Jun;166(4):1290-302.

3. Granados-Soto V, et al. Neuroscience. 2010 Jan 20;165(2):561-8.

BRL54443 (BRL 54443, BRL-54443)

生物&药学活性

物理化学性质&存储条件

参考文献

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BRL54443 (BRL 54443, BRL-54443)

生物&药学活性

物理化学性质&存储条件

参考文献

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