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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-BRD6866
BRD6866

Chemical Structure : BRD6866

CAS No.: 870780-40-8

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BRD6866

货号: PC-25401Not For Human Use, Lab Use Only.

BRD6866 is a small molecule inhibitor of TFE3 transcription factor fusion activity with IC50 of 342 nM, shows dose-dependent chromatin trapping of TFE3, potent pan-CDK inhibitor across all families of CDKs, including both cell-cycle and transcriptional CDK9, suppresses tRCC cell growth.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BRD6866 is a small molecule inhibitor of TFE3 transcription factor fusion activity with IC50 of 342 nM, shows dose-dependent chromatin trapping of TFE3, potent pan-CDK inhibitor across all families of CDKs, including both cell-cycle and transcriptional CDK9, suppresses tRCC cell growth.

物理化学性质&存储条件

分子量 375.47
分子式 C16H17N5O2S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N,4-dimethyl-5-(2-((3-(methylsulfonyl)phenyl)amino)pyrimidin-4-yl)thiazol-2-amine

参考文献

1. Dharma R Thapa, et al. bioRxiv [Preprint]. 2025 Aug 30:2025.08.25.672235.

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