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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-BRD6688
BRD6688

Chemical Structure : BRD6688

CAS No.: 1404562-17-9

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BRD6688 (BRD 6688)

货号: PC-72673Not For Human Use, Lab Use Only.

BRD6688 is a potent, kinetically selective HDAC2 inhibitor with IC50 of 21/100 nM for HDAC1/2, >115-fold selectivity versus HDAC3.

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1 mg ￥1280 In stock
5 mg ￥2580 In stock
10 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BRD6688 is a potent, kinetically selective HDAC2 inhibitor with IC50 of 21/100 nM for HDAC1/2, >115-fold selectivity versus HDAC3.
BRD6688 produced significant increases in AcH4K12 and AcH3K9 in mouse forebrain primary neuronal cultures.
BRD6688 rescued the memory defects associated with p25 induced neurodegeneration in CK-p25 induced neurodegenerative model.

物理化学性质&存储条件

分子量 282.3
分子式 C16H18N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[2-amino-5-(4-pyridinyl)phenyl]-1-pyrrolidinecarboxamide

参考文献

1. F F Wagner, et al. Chem Sci. 2015 Jan 1;6(1):804-815.

2. Wagner FF, et al. Bioorg Med Chem. 2016 Sep 15;24(18):4008-4015.

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