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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-BRD4354
BRD4354

Chemical Structure : BRD4354

CAS No.: 315698-07-8

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BRD4354 (BRD 4354)

货号: PC-62404Not For Human Use, Lab Use Only.

BRD4354 is a moderately potent, selective, reversible inhibitor of HDAC5 and HDAC9 with IC50 of 0.85 uM and 1.88 uM.

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BRD4354 is a moderately potent, selective, reversible inhibitor of HDAC5 and HDAC9 with IC50 of 0.85 uM and 1.88 uM.
BRD4354 shows weak activity against HDACs 4, 6, 7, and 8 (IC50=3.88-13.8 uM) and no inhibitory effect on other class I HDACs 1, 2, and 3 (IC50 > 40 uM).

物理化学性质&存储条件

分子量 382.892
分子式 C21H23ClN4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-chloro-7-((4-ethylpiperazin-1-yl)(pyridin-3-yl)methyl)quinolin-8-ol

参考文献

1. Boskovic ZV, et al. ACS Chem Biol. 2016 Jul 15;11(7):1844-51.

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