BRD3 PROTAC D072 | BRD3 degrader | Probechem Biochemicals

Chemical Structure : BRD3 PROTAC D072

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BRD3 PROTAC D072 (BRD3 degrader)

货号: PC-28728Not For Human Use, Lab Use Only.

BRD3 PROTAC D072 is a specific BRD3 degrader, shows potential anti-inflammatory effect in microglia.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BRD3 PROTAC D072 is a specific BRD3 degrader, shows potential anti-inflammatory effect in microglia.
D072 (10 nM) significantly inhibits proteins of iNOS, COX-2, and Galetcin-3 in LPS stimulated BV2 cells.
D072 alleviates the retinal severity of EAU and activation of retinal microglia.
D072 exerts anti-inflammatory effects by specifically degrading BRD3.
D072 (1 uM) induces significant reduction in BRD3 protein levels but has no effect on BRD2 and BRD4.
D072 mediates the specific degradation of BRD3 through CRBN.
D072 may exert its anti-inflammatory effects by modulating downstream target genes of H3K18ac.

物理化学性质&存储条件

分子量	946.09
分子式	C49H55N9O9S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(3-((1-(11-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)undecyl)-1H-1,2,3-triazol-4-yl)methoxy)phenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide

参考文献

1. Zhang Z, et al. iScience. 2025 Dec 22;29(2):114526.