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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-BRD-73954
BRD-73954

Chemical Structure : BRD-73954

CAS No.: 1440209-96-0

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BRD-73954 (BRD73954)

货号: PC-45534Not For Human Use, Lab Use Only.

BRD-73954 is the first potent, selective HDAC6/8 dual inhibitor with IC50s of 36/120 nM.

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5 mg (Free Sample) ￥180 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3680 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BRD-73954 is the first potent, selective HDAC6/8 dual inhibitor with IC50s of 36/120 nM.
BRD-73954 show no significant inhibition for other HDAC isoforms (IC50>9 uM).
BRD-73954 robustly increase in α-tubulin acetylation, has no change in the acetylation state of H3 in Hela cells.

物理化学性质&存储条件

分子量 284.3098
分子式 C16H16N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 35 mg/mL
Chemical Name/SMILES

1,3-Benzenedicarboxamide, N1-hydroxy-N3-(2-phenylethyl)-

参考文献

1. Olson DE, et al. J Med Chem. 2013 Jun 13;56(11):4816-20.

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