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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Dipeptidyl Peptidase (DPP)-BR102910
BR102910

Chemical Structure : BR102910

CAS No.: 2505339-54-6

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BR102910 (BR 102910)

货号: PC-72074Not For Human Use, Lab Use Only.

BR102910 (BR 102910) is a novel potent, selective, oral fibroblast activation protein (FAP) inhibitor with IC50 of 1 nM.

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2 mg ￥1580 In stock
5 mg ￥2580 In stock
10 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BR102910 (BR 102910) is a novel potent, selective, oral fibroblast activation protein (FAP) inhibitor with IC50 of 1 nM.
BR102910 displays high selectivity over DPPIV and prolyl oligopeptidase (PREP).
BR102910 demonstrated exceptional profiles and satisfactory FAP inhibition efficacy in vivo FAP inhibition study using C57BL/6J mice.

物理化学性质&存储条件

分子量 459.293
分子式 C18H14Cl2F2N4O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)-2-(3,4-dichlorobenzyl)thiazole-4-carboxamide

参考文献

1. Hui Jin Jung, et al. Bioorg Med Chem Lett. 2021 Apr 1;37:127846.

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