BQR-695 | PI4KIIIβ inhibitor | Probechem Biochemicals

Chemical Structure : BQR-695

CAS No.: 1513879-21-4

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BQR-695 (BQR695, NVP-BQR695)

货号: PC-61695Not For Human Use, Lab Use Only.

BQR-695 (NVP-BQR695) is a highly potent, selective PI4KIIIβ inhibitor that has high potency against both the human (IC50 = 80 nM) and PvPI4K (IC50=3.5 nM) .

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

BQR-695 (NVP-BQR695) is a highly potent, selective PI4KIIIβ inhibitor that has high potency against both the human (IC50 = 80 nM) and PvPI4K (IC50=3.5 nM).
BQR-695 shows >100 fold more potent over all other class I and class III PI3K isoforms.
BQR-695 induces a schizont-stage arrest in imidazopyrazine-treated parasites and exhibits cross-resistance with the imidazopyrazine-resistant lines.
BQR-695 is a novel antimalarial compound that inhibits the intracellular development of multiple Plasmodium species at each stage of infection in the vertebrate host.

物理化学性质&存储条件

分子量	352.394
分子式	C19H20N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide

参考文献

1. McNamara CW, et al. Nature. 2013 Dec 12;504(7479):248-253.

2. Fowler ML, et al. Protein Sci. 2016 Apr;25(4):826-39.

BQR-695 (BQR695, NVP-BQR695)

生物&药学活性

物理化学性质&存储条件

参考文献

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BQR-695 (BQR695, NVP-BQR695)

生物&药学活性

物理化学性质&存储条件

参考文献

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