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首页-小分子抑制剂&激动剂-Others-Other Targets-BPU17
BPU17

Chemical Structure : BPU17

CAS No.: 2198977-68-1

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BPU17 (BPU-17)

货号: PC-26024Not For Human Use, Lab Use Only.

BPU17 is a specific small molecule inhibitor of prohibitin, binds to prohibitin 1 (PHB1) and inhibits the PHB1-PHB2 interaction, inhibits epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells (RPEs) and exhibits antifibrotic activity in vivo.

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25 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BPU17 is a specific small molecule inhibitor of prohibitin, binds to prohibitin 1 (PHB1) and inhibits the PHB1-PHB2 interaction, inhibits epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells (RPEs) and exhibits antifibrotic activity in vivo.
BPU17 specifically binds to PHB1, but not PHB2, inhibits PHB1-PHB2 heterodimer.
BPU17 inhibits phenotypic transition of TGF-β2-stimulated RPEs.
BPU17 suppresses inflammatory stress-induced subretinal fibrosis in mouse model of retinal degeneration.

物理化学性质&存储条件

分子量 252.70
分子式 C12H13ClN2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[[(4-Chlorophenyl)amino]carbonyl]cyclobutanecarboxamide

参考文献

1. Hayashi K, et al. Exp Cell Res. 2024 Sep 1;442(1):114221.

2. Hayashi K, et al. Biochem Biophys Res Commun. 2026 Jan 31;805:153386.

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