BPR1M97 | MOP/NOP agonist | Probechem Biochemicals

Chemical Structure : BPR1M97

CAS No.: 2059904-66-2

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BPR1M97 (Dual MOP/NOP agonist)

货号: PC-38589Not For Human Use, Lab Use Only.

BPR1M97 is a dual-acting mu-opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist with Ki values of 1.8 and 4.2 nM, respectively.

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10 mg	￥3680	In stock
25 mg	￥5880	In stock
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生物&药学活性

BPR1M97 is a dual-acting mu-opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist with Ki values of 1.8 and 4.2 nM, respectively.
BPR1M97 elicited full agonist properties for all cell-based assays tested in MOP-expressing cells.
BPR1M97 acted as a G protein-biased agonist for NOP.
BPR1M97 initiated faster antinociceptive effects after subcutaneous injection and elicited better analgesia in cancer-induced pain than morphine.
BPR1M97 caused less respiratory, cardiovascular, and gastrointestinal dysfunction, compared with morphine.

物理化学性质&存储条件

分子量	349.25
分子式	C18H18Cl2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,4-Dichloro-N-[(1,2,3,4-tetrahydro-2-methyl-1-isoquinolinyl)methyl]benzamide

参考文献

1. Po-Kuan Chao, et al. Neuropharmacology. 2020 Apr;166:107678.

BPR1M97 (Dual MOP/NOP agonist)

生物&药学活性

物理化学性质&存储条件

参考文献

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BPR1M97 (Dual MOP/NOP agonist)

生物&药学活性

物理化学性质&存储条件

参考文献

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