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首页-小分子抑制剂&激动剂-GPCR-Prostaglandin Receptor-BPN-37440
BPN-37440

Chemical Structure : BPN-37440

CAS No.: 3120759-70-5

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BPN-37440 (BPN37440)

货号: PC-26564Not For Human Use, Lab Use Only.

BPN-37440 is a potent, selective prostaglandin-E2 receptor EP2 antagonist with IC50 of 53 nM, with no activity against DP1, EP4 and IP receptors.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BPN-37440 is a potent, selective prostaglandin-E2 receptor EP2 antagonist with IC50 of 53 nM, with no activity against DP1, EP4 and IP receptors.
BPN-37440 demonstrates anti-inflammatory actions in the BV2-hEP2 cellular model, and exhibits suitable in vitro ADME and in vivo PK properties.
BPN-37440 attenuates microgliosis in the amygdala, cortex, and hippocampus CA3 region 4 days following recovery from status epilepticus (SE).

物理化学性质&存储条件

分子量 346.43
分子式 C21H22N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,7-Dimethyl-N-(2-(2-methyl-1H-indol-3-yl)ethyl)-1H-pyrrolo[2,3-c]pyridine-2-carboxamide

参考文献

1. Ganesh T, et al. J Med Chem. 2026 Apr 15. doi: 10.1021/acs.jmedchem.6c00172.

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