BP1.3656B

Chemical Structure : BP1.3656B

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货号: PC-26036Not For Human Use, Lab Use Only.

BP1.3656B is a highly potent and selective histamine H3 receptor (H3R) inverse agonist/antagonist with IC50 of 0.38 nM.

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生物&药学活性

BP1.3656B is a highly potent and selective histamine H3 receptor (H3R) inverse agonist/antagonist with IC50 of 0.38 nM.
BP1.3656B reverses histamine-induced inhibition of cAMP production in forskolin-treated CHO-K1 cells stably expressing the hH3R and of the histamine-induced calcium release in HEK-293 cells stably expressing the hH3R.
BP1.3656B reduced alcohol drinking and alcohol-seeking behavior in rodents.

物理化学性质&存储条件

分子量	399.36
分子式	C20H28Cl2N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S)-4-{4-[3-(3-methylpiperidin-1-yl)propoxy]phenyl}pyridine 1-oxide dihydrochloride

参考文献

1. Le Foll B, et al. Transl Psychiatry. 2026 Jan 29;16(1):55.

BP1.3656B

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物理化学性质&存储条件

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BP1.3656B

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