BOC-D-FMK | Caspase inhibitor | Probechem Biochemicals

Chemical Structure : BOC-D-FMK

CAS No.: 634911-80-1

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BOC-D-FMK (Caspase inhibitor)

货号: PC-43410Not For Human Use, Lab Use Only.

BOC-D-FMK is a cell-permeable, irreversible, broad spectrum caspase inhibitor, inhibits apoptosis stimulated by TNF-α with IC50 of 39 uM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3480	In stock
100 mg		Get quote

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生物&药学活性

BOC-D-FMK is a cell-permeable, irreversible, broad spectrum caspase inhibitor, inhibits apoptosis stimulated by TNF-α with IC50 of 39 uM.
BOC-D-FMK inhibits TNFα-stimulated reactive oxygen species (ROS) generation, prevents genistein-induced apoptosis of p815 cells at 50 uM.
BOC-D-FMK shows neuroprotective effects on spinal motoneurons (MNs) after root avulsion in neonatal rats, suppresses polyethylene particle-induced osteolysis in mice.

物理化学性质&存储条件

分子量	263.2627
分子式	C11H18FNO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 125 mg/mL
Chemical Name/SMILES	Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester

参考文献

1. Cowburn AS, et al. Blood. 2005 Apr 1;105(7):2970-2.

2. Yee SB, et al. Exp Mol Med. 2006 Dec 31;38(6):634-42.

3. Chan YM, et al. Exp Neurol. 2003 Jun;181(2):190-203.

4. Landgraeber S, et al. Apoptosis. 2009 Feb;14(2):173-81.

BOC-D-FMK (Caspase inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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BOC-D-FMK (Caspase inhibitor)

生物&药学活性

物理化学性质&存储条件

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