BOB-42

Chemical Structure : BOB-42

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货号: PC-24850Not For Human Use, Lab Use Only.

BOB-42 is a small molecule inhibitor of RNA polymerase I (Pol I) with IC50 of 0.04 uM and 0.04 uM for degradation of RPA194 and translocation of NCL resepctively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BOB-42 is a small molecule inhibitor of RNA polymerase I (Pol I) with IC50 of 0.04 uM and 0.04 uM for degradation of RPA194 and translocation of NCL resepctively.
BOB-42 (50-100 mg/kg) is highly effective in MDM4-high and RPL22-mutant preclinical mouse models.
BOB-42 has desirable potency and DMPK properties compared to BMH-21.

物理化学性质&存储条件

分子量	374.44
分子式	C22H22N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(2S)-2-(dimethylamino)propyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide

参考文献

1. Fan W, et al. Cell Chem Biol. 2025 Jun 13:S2451-9456(25)00173-4.

2. Laureen Colis, et al. J Med Chem. 2014 Jun 12;57(11):4950-61.

BOB-42

生物&药学活性

物理化学性质&存储条件

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BOB-42

生物&药学活性

物理化学性质&存储条件

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