BNTX maleate | δ1-opioid receptor antagonist | Probechem Biochemicals

Chemical Structure : BNTX maleate

CAS No.: 864461-31-4

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BNTX maleate (7-Benzylidenenaltrexone maleate)

货号: PC-26101Not For Human Use, Lab Use Only.

BNTX (7-benzylidenenaltrexone) maleate is a selective δ1-opioid receptor antagonist with the Ki of 0.1 nM, >100-fold selective over δ2-, μ-, and κ-opioid receptors.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BNTX (7-benzylidenenaltrexone) maleate is a selective δ1-opioid receptor antagonist with the Ki of 0.1 nM, >100-fold selective over δ2-, μ-, and κ-opioid receptors.
BNTX maleate significantly reduced Helios expression in a dose-dependent manner, without altering CD8+ T cell survival in primary murine CD8+ T cells.
BNTX also sensitized pancreatic cancer cells to TRAIL-induced apoptosis by downregulating XIAP via inhibition of the PKCα/AKT signaling pathway.

物理化学性质&存储条件

分子量	545.59
分子式	C31H31NO8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-7-(phenylmethylene)-, (5α,7E)-, (2Z)-2-butenedioate (1:1) (salt)

参考文献

1. Rubio RM, et al. Cell Rep. 2025 Dec 11;44(12):116680.

2. Portoghese PS, et al. Eur J Pharmacol. 1992 Jul 21;218(1):195-6.

BNTX maleate (7-Benzylidenenaltrexone maleate)

生物&药学活性

物理化学性质&存储条件

参考文献

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BNTX maleate (7-Benzylidenenaltrexone maleate)

生物&药学活性

物理化学性质&存储条件

参考文献

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