BMY-14802 hydrochloride

Chemical Structure : BMY-14802 hydrochloride

CAS No.: 105565-55-7

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货号: PC-27162Not For Human Use, Lab Use Only.

BMY-14802 hydrochloride is a potent sigma-1 receptor (σ1R) antagonist with IC50 of 112 nM, also an agonist at serotonin 5-HT1A (IC50=320 nM) and adrenergic α-1 receptor (IC50=460 nM).

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

BMY-14802 hydrochloride is a potent sigma-1 receptor (σ1R) antagonist with IC50 of 112 nM, also an agonist at serotonin 5-HT1A (IC50=320 nM) and adrenergic α-1 receptor (IC50=460 nM).
BMY-14802 does not bind with high affinity to the D1 or D2 receptor (IC50s>1,000 and 6,430 nM, respectively).
BMY-14802 suppresses not only AIM but also L-DOPA-induced rotation.
The AIM-suppressing action of BMY-14802 is dependent on 5-HT1A but not adrenergic α-1 receptors, as this effect is prevented by the 5-HT1A antagonist WAY-100653 but not the α-1 antagonist prazosin.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-fluorophenyl)-1-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)butan-1-ol hydrochloride

参考文献

1. Paquette MA, et al. sychopharmacology (Berl). 2009 Jul;204(4):743-54.

2. Yevich JP, et al. J Med Chem. 1992;35:4516–4525.