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BMX inhibitor B6a

Chemical Structure : BMX inhibitor B6a

CAS No.: 2657662-64-9

BMX inhibitor B6a (BMX-IN-3)

货号: PC-27276Not For Human Use, Lab Use Only.

BMX inhibitor B6a (BMX-IN-3) is a potent, selective and irreversible BMX kinase with IC50 of 12 nM, displays good antiproliferative activities in various cancer cell lines, promotes cell cycle arrest and apoptosis, triggers protective autophagy, and suppresses the BMX/AKT/mTOR pathway.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BMX inhibitor B6a (BMX-IN-3) is a potent, selective and irreversible BMX kinase with IC50 of 12 nM, displays good antiproliferative activities in various cancer cell lines, promotes cell cycle arrest and apoptosis, triggers protective autophagy, and suppresses the BMX/AKT/mTOR pathway.

物理化学性质&存储条件

分子量 467.55
分子式 C22H25N7O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-N2-(3-phenoxyphenyl)-N4-(1-(vinylsulfonyl)piperidin-3-yl)-1,3,5-triazine-2,4,6-triamine

参考文献

1. Nan Wang, et al. J Med Chem. 2025 Feb 27;68(4):4196-4216.

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